Metabolic regulation by p53 family members

The function of p53 is best understood in response to genotoxic stress, but increasing evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis. p53 and its family members directly influence various metabolic pathways, enabling cells to respond to metabolic stress. These functions are likely to be important for restraining the development of cancer but could also have a profound effect on the development of metabolic diseases, including diabetes. A better understanding of the metabolic functions of p53 family members may aid in the identification of therapeutic targets and reveal novel uses for p53-modulating drugs

Correlated outcomes of a pilot intervention for people injecting drugs and their family members in Vietnam.

BackgroundThe interrelationship between the well-being of injecting drug users (IDUs) and their family environment has been widely documented. However, few intervention programs have addressed the needs of both IDUs and their family members.MethodsThis study describes a randomized intervention pilot targeting 83 IDUs and 83 of their family members from four communes in Phú Thọ province, Vietnam. The IDUs and family members in the intervention condition received multiple group sessions, with the intent to improve psychological well-being and family relationships. The intervention outcomes (depressive symptoms and family relations) were evaluated at baseline, 3-month and 6-month follow-up assessments.ResultsDepressive symptoms and family relations reported by IDUs were found to be correlated to those reported by their family members. Overall, significant intervention effects on depressive symptoms and family relations were observed for both IDUs and family members. A similar improvement pattern in family relations emerged for both the IDU and family member samples, although the intervention effect of reducing depressive symptoms was more sustainable for family members at the 6-month assessment when compared to the IDU sample.ConclusionThe intervention pilot addressed challenges faced by IDUs and their family members and revealed correlated outcomes for the two groups. Findings suggest a vital need to include family members in future drug prevention and harm reduction intervention efforts

Family support groups for family members of mentally ill offenders : family expectations and experiences

Family Support Groups (FSGs) are developed for family members of mentally ill offenders. This study investigates family treatment expectations and experiences of an FSG. Family members were interviewed before (n = 20) and after (n = 17) attending an FSG. Results show that family members hesitated or were curious about the FSG, expected to receive peer support and universality of problems, to receive information and advice and thought about the safety and respect of the group. Family members experienced the treatment as helpful because it was supportive, they gained new insights and they felt relieved and satisfied. Many family members see the guidance of the therapists and the differences in family and gender roles as an added value of attending an FSG. However, considering the limitations of the study, future studies should gain insight in and stress the importance of the meaning of therapeutic processes for family members confronted with different psychiatric disorders and/or situations

Family support groups for family members of mentally ill offenders : a pilot study

To date, there is a lack of family interventions for family members of persons with a mental illness who offended (PMIO). With the aim of addressing this issue, a Family Support Group (FSG) has been developed. The current pilot study investigated the impact of two pilot FSGs for family members of PMIO in relation to quality of life, burden, coping strategies, and resilience. Family members completed several questionnaires (i.e. WHOQOL-BREF, ZBI-22, CERQ, RS-nl) both before and after the group intervention. A total of 20 family members participated in both FSGs. The results indicated that participants experienced less self-blame, a decrease in loss of control over their lives, and improved emotional well-being. The findings showed that attending an FSG can be empowering for family members as it offers support in the management of emotional experiences and coping strategies

The impact of patients' chronic disease on family quality of life : an experience from 26 specialties

BACKGROUND: Previous studies have assessed family quality of life in individual disease areas and specialties. The aim of this study was to investigate the impact of disease on family members of patients over a wide range of specialties and identify key impact areas. This information is essential in order to reveal the extent of this impact and to allow strategies to be developed to support the family members of patients with chronic disease. METHODS: Semi-structured interviews were carried out with 133 family members of mostly chronically ill patients from 26 medical specialties. Family members were invited to discuss all areas of their lives that had been affected by having an unwell relative. Thematic analysis was carried out using NVivo9® software. RESULTS: Most family members were female (61%), the partner or spouse of the patient (56%), or the parent (22%). Their mean age was 56.1 years (range: 21-85 years) and the mean duration of the patient's disease was 8.9 years (range: 1 month to 60 years). Ten key themes of family quality of life were identified from interviews. The median number of themes reported by family members was six (range: 1-10). The key themes included: emotional impact (mentioned by 92% of subjects), daily activities (91%), family relationships (69%), sleep and health (67%), holidays (62%), involvement in medical care and support given to family members (61%), work and study (52%), financial impact (51%), social life (37%), and time planning (14%). Relationships between the themes were identified. CONCLUSION: This large scale multi-specialty study has demonstrated the significant, yet similar, impact that illness can have on the quality of life of patients' family members. Family quality of life is a previously neglected area of health care which needs to be addressed in order to provide appropriate support for the patient and the family unit.Peer reviewedFinal Published versio

The impact of gambling problems on families

Summarises the available research about how gambling problems affect family relationships and family members, how families cope with gambling problems, and the assessment and therapy options available to the family members of people with gambling problems. Summary Gambling problems can have severe personal consequences, including financial hardship, emotional difficulties, social impacts, employment difficulties and legal problems. They can also have significant impacts on families and communities. It has been estimated that the gambling problem of one Australian negatively affects at least seven other people. The impact of gambling problems on families has received relatively little research attention. Although most available information is based on intimate partners and children, gambling problems can also affect extended family members such as parents, grandparents and siblings. This discussion paper summarises the available research about how gambling problems affect family relationships and family members, how families cope with gambling problems, and the assessment and therapy options available to the family members of people with gambling problems

Characterisation of candidate members of (136108) Haumea's family

Ragozzine & Brown [2007] presented a list of candidate members of the first collisional family to be found among the trans-Neptunian Objects (TNOs), the one associated with (136108) Haumea (2003 EL61). We aim to identify which of the candidate members of the Haumea collisional family are true members, by searching for water ice on their surfaces. We also attempt to test the theory that the family members are made of almost pure water ice by using optical light-curves to constrain their densities. We use optical and near-infrared photometry to identify water ice, in particular using the (J - H_S) colour as a sensitive measure of the absorption feature at 1.6 micron. We use the CH_4 filter of the new Hawk-I instrument at the VLT as a short H-band (H_S) for this as it is more sensitive to the water ice feature than the usual H filter. We report colours for 22 candidate family members, including NIR colours for 15. We confirm that 2003 SQ317 and 2005 CB79 are family members, bringing the total number of confirmed family members to 10. We reject 8 candidates as having no water ice absorption based on our Hawk-I measurements, and 5 more based on their optical colours. The combination of the large proportion of rejected candidates and time lost to weather prevent us from putting strong constraints on the density of the family members based on the light-curves obtained so far; we can still say that none of the family members (except Haumea) require a large density to explain their light-curve.Comment: 9 pages, 5 figures, accepted for publication in A&

Some Culp Family Members in the Civil War

In the 1860s Gettysburg had a population of around 2,400. The Culps had lived there since 1787, the year Christopher Culp purchased the farm, located on the east end of town, with its western boundry starting at Baltimore St. between Breckenridge and South Streets, going northeast to South Stratton St. and Wall Alley East, then on to East Middle St. between South Stratton and Liberty Streets. The town more or less ended at the farm boundary. Prominent on the farm and southeast of town was Culp\u27s Hill. Five generations of Culps had lived in Gettysburg by the time of the battle. [excerpt